SERS INVESTIGATIONS OF 2-METHOXY-2-METHYLPROPYLISONITRILE (MIBI) AND ITS TECHNETIUM COMPLEX

Authors

  • George CRIȘAN Babeş-Bolyai University, Faculty of Physics, 1 Kogălniceanu, RO-400084 Cluj-Napoca, Romania; Department of Nuclear Medicine, County Clinical Hospital, 3-5 Clinicilor, RO-400006 Cluj-Napoca, Romania
  • Ana Maria MACEA Babeş-Bolyai University, Faculty of Physics, 1 Kogălniceanu, RO-400084 Cluj-Napoca, Romania
  • Gabriel ANDRIEȘ Department of Nuclear Medicine, County Clinical Hospital, 3-5 Clinicilor, RO-400006 Cluj-Napoca, Romania
  • Vasile CHIŞ Babeş-Bolyai University, Faculty of Physics, 1 Kogălniceanu, RO-400084 Cluj-Napoca, Romania https://orcid.org/0000-0002-0935-4134

DOI:

https://doi.org/10.24193/subbphys.2021.03

Keywords:

Technetium; radiopharmaceuticals; SPECT; MIBI; SERS.

Abstract

Technetium radiopharmaceuticals remain the most widely available and cost-effective compounds used in nuclear medicine imaging. However, exact information regarding the chemical structure of these compounds is scarce. In this study we present a spectroscopic investigation of Hexakis (2-methoxy-2-methylpropylisonitrile) (MIBI) Technetium (99mTc) (99mTc-sestamibi). Surface Enhanced Raman Scattering spectra of the ligand and the Technetium sestamibi complex were recorded. For the later, the measurements were recorded in solution as administered to patients and at different moments from the time of preparation in order to monitor its stability. The information provided by the vibrational characterization of the MIBI ligand allowed us to understand spectroscopic features pertaining to the SERS spectra of the Technetium complex.

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STUDIA UBB PHYSICA, Volume 66 (LXVI), No. 1-2, December 2021

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Published

2021-12-30

How to Cite

CRIȘAN, G., MACEA, A. M., ANDRIEȘ, G., & CHIŞ, V. (2021). SERS INVESTIGATIONS OF 2-METHOXY-2-METHYLPROPYLISONITRILE (MIBI) AND ITS TECHNETIUM COMPLEX. Studia Universitatis Babeș-Bolyai Physica, 66(1-2), 31–37. https://doi.org/10.24193/subbphys.2021.03

Issue

Volume 66, No. 1-2, 2021

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Articles

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