XRD CHECKING OF CRYSTALLINE FORMS RESULTED BY SLOW EVAPORATION OF 5-FLUOROURACIL SOLUTIONS OBTAINED WITH DIFFERENT SOLVENTS

Authors

  • C. MOISESCU-GOIA Faculty of Physics & Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, 400084 Cluj-Napoca, Romania; Nuclear Medicine Department, Ion Chiricuta Institute of Oncology, 400015 Cluj-Napoca, Romania
  • M. MURESAN-POP Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, 400084 Cluj-Napoca, Romania. marieta.muresan@ubbcluj.ro https://orcid.org/0000-0003-4460-9654
  • V. SIMON Faculty of Physics & Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, 400084 Cluj-Napoca, Romania; Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, 400084 Cluj-Napoca, Romania. viosimon@phys.ubbcluj.ro

DOI:

https://doi.org/10.24193/subbphys.2017.02

Keywords:

5-fluorouracil; solubility; X-ray diffraction; polymorphs.

Abstract

The present study aimed to obtain new crystalline forms of 5-fluorouracil (5-FU) chemotherapy drug after 5-FU solvation in different solvents, considering the crystallization by slow evaporation. The expectation was to obtain 5-FU polymorphs. 5-FU was tested in aqueous solutions of 14 solvents. After slow evaporation of solutions (11) or suspensions (3), the obtained crystalline forms were examined by checking their X-ray diffraction patterns. Only for acetonitrile solution resulted a polymorph of 5-FU.

References

M. Davidovich, J.Z. Gougoutas, R.P. Scaringe, I. Vitez, S. Yin, Detection of polymorphism by powder X-ray diffraction: Interference by preferred orientation, Am. Pharm. Rev., 2004, 7, 10-16.

V. Sharma, N. Chitranshi, A.K. Agarwal, Significance and biological importance of pyrimidine in the microbial world, Int. J. Med. Chem., 2014 (2014), Article ID 202784.

J.L. Grem, 5-Fluorouracil: Forty-plus and still ticking. A review of its preclinical and clinical development, Invest. New Drugs, 2000, 18, 299–313.

N. Zhang, Y. Yin, S.J. Xu, W.S. Chen, 5-Fluorouracil: Mechanisms of resistance and reversal strategies, Molecules, 2008, 13, 1551–1569.

D.B. Longley, D.P. Harkin, P.G. Johnston, 5-fluorouracil: Mechanisms of action and clinical strategies, Nat. Rev. Cancer, 2003, 3 330–338.

S. Li, J.-M. Chen, T.-Bu. Lu, Synthon polymorphs of 1 : 1 co-crystal of 5-fluorouracil and 4-hydroxybenzoic acid: their relative stability and solvent polarity dependence of grinding outcomes, CrystEngComm, 2014, 16, 6450-6458

A. Ainouz, J.-R. Authelin, P. Billot, H. Lieberman, Modeling and prediction of cocrystal phase diagrams, International Journal of Pharmaceutics, 2009, 374, 82-89.

G. Engelhardt, J. Felsche, P. Sieger, The Hydrosodalite System Na6+x[SiAlO4]6(OH)x∙nH20: Formation, phase composition, and de- and rehydration studied by 1H, 23Na, and 29Si MAS-NMR spectroscopy in tandem with thermal analysis, X-ray diffraction, and IR spectroscopy, J. Am. Chem. Soc., 1992, 114, 1173-1182.

STUDIA UBB PHYSICA, Volume 62 (LXII), No. 1-2, December 2017

Downloads

Published

2017-12-30

How to Cite

MOISESCU-GOIA, C., MURESAN-POP, M., & SIMON, V. (2017). XRD CHECKING OF CRYSTALLINE FORMS RESULTED BY SLOW EVAPORATION OF 5-FLUOROURACIL SOLUTIONS OBTAINED WITH DIFFERENT SOLVENTS. Studia Universitatis Babeș-Bolyai Physica, 62(1-2), 15–21. https://doi.org/10.24193/subbphys.2017.02

Issue

Volume 62, No. 1-2, 2017

Section

Articles

License

Copyright (c) 2017 Studia Universitatis Babeș-Bolyai Physica

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.